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PDF Deciphering the Role of V88L Substitution in NDM-24 Metallo- -Lactamase
Download scientific diagram | Proportions of various secondary structural elements in the NDM-1, NDM-5, and NDM-24 enzymes. from publication: Deciphering the Role of V88L Substitution in NDM-24...
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Proportions of various secondary structural elements in the NDM-1 ...
The NDM-5 variants were found harbouring V88L and M154L mutations. • The NDM variants were found harboring other antibiotic resistance markers, plasmid replicons and virulence genes. • It is essential to resolve the genetic insights of the evolving NDM variants for infection control and correct therapeutics
Plasmid-Mediated Novel
NDM-17 shares the V88L and M154L substitutions with NDM-5, in addition to E170K. Our kinetic data showed that NDM-17 had a significantly higher affinity for all β-lactams tested and obviously increased catalytic efficiencies for cefoxitin and penicillin G.
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