• Acesulfame potassium - Wikipedia
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Acesulfame potassium - Wikipedia

As a multi-function enzyme, AceK integrates kinase, phosphatase and ATPase activities in a single active site. In contrast to most kinases, AceK exhibits unusually high ATPase activity compared to its kinase and phosphatase activities.

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We found that AceK consumption enhanced hepatic lipogenesis and decreased β-oxidation in ApoE−/− mice. In addition, AceK directly increased lipogenesis and decreased β-oxidation in HepG2 cells.

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Here we report the structures of AceK and its complex with ICDH. The AceK structure reveals a eukaryotic protein-kinase-like domain containing ATP and a regulatory domain with a novel fold.